诊断为慢性淋巴细胞白血病 (CLL) 的美国退伍军人治疗模式和结果
Helen Ma1, Susan O'Brien2, Pankaj Gupta3
1VA Long Beach Healthcare System, Long Beach, CA; University of California Irvine, Orange, CA.
Clinical lymphoma, myeloma & leukemia
|September 24, 2023
概括
针对性治疗显著改善了美国退伍军人慢性淋巴细胞白血病 (CLL) 的整体存活率,这些退伍军人事务 (VA) 系统管理. 这项为期20年的分析表明,VA患者接受了基于证据的护理,有针对性的治疗可以在所有环境中延长存活时间.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 美国退伍军人在退伍军人事务 (VA) 医疗保健系统中得到照顾,这是一个国家单一支付系统.
- 在VA系统中,可以获得FDA批准的慢性淋巴细胞白血病 (CLL) 等疾病的治疗方法.
研究的目的:
- 描述在VA系统中管理的慢性淋巴细胞白血病 (CLL) 的处方模式和患者结局.
- 分析20年来第一线治疗的趋势,并确定与CLL患者生存相关的因素.
主要方法:
- 从1999年1月到2020年12月在VA管理的CLL诊断的成年患者的回顾性分析.
- 二十年来对一线治疗模式的评估.
- 对未接受治疗和接受治疗的CLL患者队列中与生存相关的因素的分析.
主要成果:
- 分析了16331名CLL患者的队列,平均整体存活时间 (OS) 为8.7年.
- 第一线治疗随着时间的推移而演变,反映了针对性治疗的批准.
- 与从未接受向治疗 (3.5年) 的患者相比,暴露于第一线或后期的向治疗与显著更长的生存期 (8.5年) 相关.
结论:
- 在VA系统中接受治疗的退伍军人在过去20年中接受了与当前基于证据的实践相一致的疗法.
- 用向疗法的治疗与CLL患者的初始和复发/耐药设置中改善的中位数OS有关.
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