偏头痛中的无声脑梗塞:系统审查和元分析
A Espanol1, F Lerebours1, L Calviere1
1Department of Neurology, University Hospital of Toulouse, Toulouse, France.
Revue neurologique
|September 24, 2023
概括
偏头痛,特别是带有光环的偏头痛,在基于人群的研究中与无声性脑梗塞无关. 然而,一个探索性分析表明,偏头痛与光环和静音脑梗塞之间可能存在关联.
科学领域:
- 神经学 神经学
- 神经成像是一种神经成像.
- 流行病学 流行病学
背景情况:
- 偏头痛,特别是带有光环的偏头痛,是缺血性中风的已知危险因素.
- 偏头痛和无声脑梗塞之间的关系仍然存在争议,因为研究结果相互矛盾.
研究的目的:
- 系统地审查和元分析偏头痛与静音脑梗塞之间的关联.
- 通过基于人口的和临床的研究来调查偏头痛与光环和静音脑梗塞之间的联系.
主要方法:
- 从1980年1月到2022年4月,在Medline和Embase数据库上进行了全面的文献搜索.
- 包括报告的偏头痛和磁共振成像检测到的静音脑梗塞的研究.
- 对基于人群的研究进行了元分析,对基于人群和临床研究的综合研究进行了额外的探索性分析.
主要成果:
- 对基于人群的研究进行的元分析发现,偏头痛与静音脑梗塞 (OR=1.32) 或偏头痛与光环和静音脑梗塞 (OR=1.56) 之间没有显著的关联.
- 结合基于人口和临床研究的探索性元分析显示,偏头痛与光环和静音脑梗塞之间存在显著的关联 (OR=1.91).
- 这项探索性分析还表明,偏头痛与光环和静音小脑梗塞 (OR=2.57) 之间存在显著的关联.
结论:
- 当考虑基于人口的研究时,偏头痛和带有光环的偏头痛与无声性脑梗塞无关.
- 带有光环的偏头痛可能与静音脑梗塞和静音小脑梗塞有关,特别是当将临床研究纳入分析时.
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