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脂质体谷补充剂减轻了肝脏和脏的肺外结核病

Kayvan Sasaninia¹, Melissa Kelley², Arbi Abnousian¹

¹College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA.

Frontiers in bioscience (Elite edition)

|September 24, 2023

概括

脂质体谷氨 (L-GSH) 补充剂在外肺结核 (EPTB) 鼠标模型中降低了氧化应激和Mycobacterium结核病 (M. tb) 负担. 这种方法显示出对抗M. tb感染的新型治疗干预措施的希望.

科学领域:

免疫学免疫学免疫学
微生物学微生物学
药理学药理学是指药理学的学科.

背景情况:

肺外结核病 (EPTB) 在全球范围内占结核菌菌 (M. tb) 感染的很大一部分.
耐多药性和抗生素诱导的肝毒性使结核病管理复杂化,需要新的治疗策略.
脂质体谷氨 (L-GSH) 已在肺结核模型中显示出有效性,但其在EPTB中的作用,特别是在肝脏和脏中,仍然未被探索.

研究的目的:

调查L-GSH补充剂对氧化应激标志物,细胞因子概况以及在活性EPTB期间肝脏和脏中的M. tb负担的影响.
评估L-GSH对宿主的保护作用,在影响肺外器官的M. tb感染的小鼠模型中.

主要方法:

在未接受治疗和接受L-GSH治疗的野生型 (WT) 感染M. tb的小鼠中,评估肝脏中的谷氨 (GSH) 和麦隆迪 (MDA) 水平.
对细胞因子 (IL-6,IFN-γ,TNF-α,IL-10) 对L-GSH治疗的反应进行分析.
量化肝脏和脏M. tb.负担和组织病理的评估.

主要成果:

补充L-GSH增加了肝脏总GSH水平,并减少了氧化GSH和MDA.
治疗调节了细胞因子配置,增加了促炎性IFN-γ和TNF-α,同时降低了抗炎性IL-10和IL-6.
观察到肝脏和脏M. tb负担的显著减少,以及这些器官的宿主保护作用.

结论:

补充L-GSH通过减轻氧化应激和调节免疫反应,有效地减少肝脏和中的M. tb负担.
观察到有益细胞因子的增加和有害细胞因子的减少凸显了L-GSH的治疗潜力.
L-GSH代表了一种有前途的宿主导治疗策略,用于管理活跃的肺外结核病.

关键词:

肺外结核是肺外结核的一种疾病.葡萄糖氨酸氨酸是什么?肝脏肝脏肝脏肝脏肝脏肝脏氧化应激是一种氧化应激.脊髓脊髓脊髓是一个结核病是一种肺结核病.

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