合成,表征,生化和分子建模研究基于卡瓦克罗尔的新型 thiosemicarbazide 和 1,3,4-thiadiazole 衍生物

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Tenzile Alagöz1, Fatma Güneş Çalişkan1, Hayriye Genç Bilgiçli1

  • 1Department of Chemistry, Faculty of Sciences, Sakarya University, Sakarya, Turkiye.

Archiv der Pharmazie
|September 24, 2023
PubMed
概括

基于卡瓦克罗尔的新型 thiosemicarbazide 和 1,3,4-thiadiazole-2-amine 衍生物显示出对人类碳酸无水酶 I 和 II,乙胆酶和丁胆酶酶的强烈抑制. 分子对接证实了高亲和力,表明了治疗潜力.

关键词:
1,3,4-提亚迪亚佐尔 (thiadiazole) 是一种可以酶抑制抑制酶的抑制.分子对接的分子对接.综合合成是一种合成.这种类型的二氧化基化.

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