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莫尔努皮拉维尔的使用:丹麦全国药物使用研究

Louise Ladebo¹, Lotte Rasmussen¹, Peter Bjødstrup Jensen¹

¹Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health, University of Southern Denmark, Odense, Denmark.

Pharmacoepidemiology and drug safety

|September 24, 2023

概括

摩尔努皮拉维尔 (Molnupiravir) 是一种用于COVID-19的口服抗病毒药物,主要由全科医生给具有并发病的老年患者开处方. 使用与指导方针一致,表明对高风险个体的适当使用.

科学领域:

药理学和公共卫生
传染病流行病学传染病流行病学

背景情况:

莫尔努皮拉维尔是一种口服抗病毒药物,用于治疗轻度至中度的COVID-19.
了解其现实世界的使用对于评估治疗有效性和遵守指南至关重要.

研究的目的:

在丹麦描述molnupiravir的使用模式.
为了确定molnupiravir用户和处方者的人口和临床特征.
为了评估对molnupiravir的处方指南的遵守.

主要方法:

来自丹麦的全国注册数据 (2021年12月 - 2022年8月).
对molnupiravir的处方数据的分析.
摩尔努皮拉维尔使用者与匹配的,未经治疗的SARS-CoV-2阳性个体的比较.

主要成果:

5,847人接受了molnupiravir;发生率上升到每1000个阳性测试中的16个处方.
使用者主要是男性 (55%),平均年龄为74岁,并具有高的并发症负担 (中位数为3) 和养老院住院 (12%).
一般医生 (91%) 是主要的处方者,大多数处方是在阳性SARS-CoV-2测试后5天内发布的.

结论:

莫尔努皮拉维尔主要由全科医生给高风险的COVID-19患者开处方.
处方模式表现出高度遵守既定治疗指南.
这项研究强调了molnupiravir在现实环境中的适当使用.

关键词:

在 COVID-19 疫情中,抗病毒药物抗病毒药物使用药物使用药物使用.莫尔努皮拉维尔 (Molnupiravir) 是一种药学流行病学药学流行病学

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