基线肠道微生物群和代谢组预测了对SARS-CoV-2疫苗的持久免疫性
Ye Peng1,2,3, Lin Zhang1,4, Chris K P Mok2,3
1Microbiota I-Center (MagIC), Hong Kong, China.
Signal transduction and targeted therapy
|September 24, 2023
概括
肠道微生物和代谢物影响COVID-19疫苗免疫耐久性. 特定的细菌和营养物质,如尼古丁酸和L-三,与BNT162b2和CoronaVac疫苗接种后的持续抗体水平相关.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物组研究 微生物组研究
- 疫苗学 疫苗学 疫苗学
背景情况:
- 针对SARS-CoV-2的疫苗诱导免疫力的持久性对于长期保护至关重要.
- 肠道微生物群对疫苗反应的影响,特别是其长期影响,仍然不完全理解.
研究的目的:
- 研究肠道微生物群组成和代谢组与对COVID-19疫苗 (BNT162b2和CoronaVac) 免疫反应的耐久性之间的联系.
- 识别潜在的微生物或代谢生物标志物,预测疫苗接种后持续的抗体水平.
主要方法:
- 一项涉及121名BNT162b2和40名CoronaVac疫苗接种者的队列研究.
- 在接种疫苗后的基线,1个月和6个月收集血液和便样本.
- 分析中和抗体水平,血细胞因子,化学因子,肠道微生物组合和代谢组.
主要成果:
- 特定细菌 (例如,Bifidobacterium spp.,Roseburia faecis) 和代谢物 (尼古丁酸,γ-氨基黄油酸) 的较高基线水平与BNT162b2疫苗接种者在6个月后更高的中和抗体有关.
- 对于CoronaVac接种者来说,较高的中和抗体与特定的细菌丰度 (Phocaeicola dorei,Dorea formicigenerans) 和L-托水平有关.
- 在接种CoronaVac后,微生物群的多样性下降,并且在6个月内没有恢复.
结论:
- 肠道微生物群的组成和特定的代谢物在调节COVID-19疫苗免疫力的持久性方面发挥着作用.
- 某些肠道微生物和代谢物可能充当辅助剂,可能增强疫苗的长期疗效.
- 研究结果表明,基于微生物组资料的个性化策略可以优化疫苗反应.
相关概念视频
Microorganisms in Medicine and Therapeutics
49
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
49
Immunological Memory
652
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
652
Anatomy of the Intestines
72.3K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
72.3K


