分泌的LRPAP1结合并触发IFNAR1降解,以促进病毒从细胞天生的免疫力中逃避病毒

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Updated: Jul 15, 2025

Monitoring Activation of the Antiviral Pattern Recognition Receptors RIG-I And PKR By Limited Protease Digestion and Native PAGE
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Monitoring Activation of the Antiviral Pattern Recognition Receptors RIG-I And PKR By Limited Protease Digestion and Native PAGE

Published on: July 29, 2014

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Huangcan Li1,2, Xiong Wang1, Yiran Wang1

  • 1Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, China.

Signal transduction and targeted therapy
|September 24, 2023
PubMed
概括

像SARS-CoV-2和EV71这样的病毒使用一种分泌的蛋白质LRPAP1,通过降低IFNAR1.1来禁用宿主干扰素免疫力. 这一发现揭示了一种新的病毒逃避策略,以及开发泛抗病毒药物的潜力.

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