梅尼尔氏病和过敏:流行病学,病原和治疗方法
Wandi Xu1,2, Xiaofei Li1,2,3, Yongdong Song1,2,3
1Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, Shandong, China.
Clinical and experimental medicine
|September 24, 2023
概括
过敏可能导致Ménière.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 免疫学 免疫学 免疫学
- 病理生理学 病理生理学
背景情况:
- 关于Ménière病 (MD) 的确切原因仍在争论中.
- 近一个世纪以来,人们已经观察到过敏和MD之间的潜在联系.
- 以前的审查主要集中在临床流行病学上,忽视了其他关键方面.
研究的目的:
- 从多个角度探索过敏和MD之间的关联.
- 审查流行病学,免疫学,病理生理学和免疫治疗证据.
- 在人类患者和动物模型中调查过敏的作用.
主要方法:
- 综合文献综述,重点关注免疫学,病理生理学和免疫疗法.
- 分析涉及梅涅尔病患者和动物模型的研究.
- 检查过敏调解剂和抗过敏疗法的影响.
主要成果:
- 患有MD的患者经常表现出并发性过敏和积极的过敏免疫学标志物.
- 像IgE这样的过敏媒介可能会加剧MD症状,在内耳中发现IgE沉积物.
- 过敏挑战可以在人类和动物中引发头,而抗过敏治疗显示出有前途.
结论:
- 过敏是Ménière病病因学的重要因素,影响其免疫学和病理生理学.
- 内耳的免疫反应和过敏媒介的影响需要进一步研究.
- 通过免疫疗法向过敏可能为Ménière病提供治疗策略.
相关概念视频
Asthma: Pathogenesis and Management
433
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
433
Allergic Reactions
27.7K
Overview
27.7K
Pathophysiology of Vomiting
558
Vomiting is a complex physiological response to expel harmful or irritating substances from the body. It's a defensive mechanism triggered by stimuli like poisons, microbial toxins, cytotoxic drugs, and mechanical abdominal distension. The process is centrally coordinated by the vomiting (or emetic) center located in the medulla of the brainstem. This area, rich in muscarinic M1, histamine H1, neurokinin 1 (NK1), and serotonin 5-HT3 receptors, coordinates the act of vomiting through...
558
Allergic Drug Reactions
873
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
873
Asthma-II: Pathophysiology and Classification
2.7K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.7K
Equilibrium and Balance
4.8K
The inner ear assumes dual functionalities of auditory perception and equilibrium maintenance. The vestibule is the organ responsible for balance. This organ contains mechanoreceptors, specifically hair cells, endowed with stereocilia, which aid in deciphering information regarding the position and motion of our heads. Two intrinsic components, the utricle and saccule, help perceive head position, while the semicircular canals track head movement. Neurological messages initiated in the...
4.8K


