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Sargassum fusiforme 提取物对主要珊瑚病原体具有分子对接和抗菌活性

Nedaa Ahmed^1,2,3, Mohamed A M El-Tabakh⁴, Hala F Mohamed^5,6

¹Third Institute of Oceanography, Ministry of Natural Resources, Xiamen, 361005, People's Republic of China. nedaahussain.5922@azhar.edu.eg.

World journal of microbiology & biotechnology

|September 24, 2023

概括

来自Sargassum fusiforme的海藻提取物对珊瑚病原体具有强大的抗菌活性. 类化合物和n-hexane提取物有效地对抗威胁Porites lutea珊瑚健康的细菌.

科学领域:

海洋生物学海洋生物学
微生物学微生物学
药理学药理学是指药理学的学科.

背景情况:

珊瑚礁,包括Porites lutea,受到细菌病原体的威胁.
识别新型抗菌剂对于珊瑚保护工作至关重要.

研究的目的:

为了评估 Sargassum fusiforme 提取物对珊瑚病原体的抗菌特性.
为了确定负责抗菌作用的特定生物活性化合物.

主要方法:

在体外抗菌试验中使用原始提取物 (乙醇,n-hexane,乙烯酸) 和类.
气色谱-质谱 (GC-Mass) 用于化合物分析.
对细菌蛋白质 (Hemolysin 和 Cytoplasmic) 的分子对接模拟.

主要成果:

化物和n-hexane提取物对测试的珊瑚病原体表现出显著的抗菌活性.
在n-hexane提取物中,GC-Mass确定了38种化合物,其中12种已知具有生物活性.
分子对接证实了6-O-Palmitoyl-L-ascorbic酸,甘油单酸衍生物和伊可索诺酸的抗菌潜力.

结论:

藻状提取物,特别是化物和n-hexane,是对珊瑚疾病管理有前途的天然抗菌剂.
鉴定到的特定化合物显示出作为珊瑚治疗药物进一步开发的巨大潜力.

关键词:

具有抗菌活性,具有抗菌活性.珊瑚病原体的病原体对接分析对接分析波里特斯·卢泰亚 (Porites lutea) 是一个紫色的动物.体体体 (Sargassum fusiforme) 是一种体体.n-赫克桑是什么意思 n-赫克桑是什么意思

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