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聚醇对DNA甲基化评估的生物衰老减弱的影响:DIRECT PLUS随机对照试验

Anat Yaskolka Meir^1,2, Maria Keller^3,4, Anne Hoffmann³

¹The Health & Nutrition Innovative International Research Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, P.O. Box 653, 8410501, Be'er Sheva, Israel.

|September 24, 2023

概括

富含多的饮食,包括绿茶和曼开,在临床试验中与缓慢的生物衰老有关. 这表明饮食中的多可能会影响表观遗传年龄和整体衰老过程.

科学领域:

表观遗传学和衰老研究.
营养科学和代谢
微生物群和健康问题

背景情况:

通过DNA甲基化进行表观遗传年龄估计,可以提供对生物衰老的见解.
以前的研究将多醇摄入量与改善的健康标志物联系起来.
富含多的饮食对生物衰老的影响仍未确定.

研究的目的:

调查富含多的饮食干预措施对表观遗传年龄的影响.
评估地中海饮食 (MED) 和绿色MED饮食后生物衰老标志物的变化.
探索饮食,尿液多和生物衰老之间的关联.

主要方法:

一个为期18个月的随机对照试验 (DIRECT PLUS) 涉及256名参与者.
计算多个表观遗传年龄钟 (例如,Horvath2013,Hannum2013,Li2018) 和DunedinPACE.
干预措施包括地中海饮食和富含多的绿色MED饮食,其中包括绿茶和曼开;通过问卷和尿液代谢学评估的坚持.

主要成果:

对绿色MED饮食的更强的坚持与Li和Hannum时钟中的降低甲基化年龄 (mAge) 加速相关.
更高的曼开和绿茶摄入量与更大的Li mAge衰减有关.
尿中多醇 (氧醇,醇,乌罗素C) 的增加与mAge的变化有关;MED式饮食显示Li mAge的8.9个月的差异.

结论:

富含多的MED和Green-MED饮食,如绿茶和Mankai,与生物衰老相反地相关.
这项研究提供了第一个临床试验证据,表明聚醇摄入量,尿液代谢产物和减少生物衰老之间的联系.
饮食干预可以潜在地调节表观遗传衰老过程.

关键词:

表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.绿色的MED饮食是绿色的MED饮食甲基化年龄甲基化年龄泰罗索尔 (Tyrosol) 是一种光剂.尿液中的代谢组分.乌罗利素是一种乌罗利素.减肥的方法减肥的方法减肥的方法

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