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发现了预防癌症的果汁,重新激活了RB功能
Mitsuharu Masuda1, Mano Horinaka2, Shusuke Yasuda2
1Department of Molecular-Targeting Prevention, Kyoto Prefectural University of Medicine.
像卡卡杜梅和石榴这样的天然果汁可以重新激活瘤抑制器视网膜母细胞瘤基因 (RB) 功能. 这项研究表明,这些果汁与乳酸细菌一起,可以通过抑制细胞生长和减少癌前病变来预防结肠癌.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 营养科学 营养科学
背景情况:
- 癌症遗传学的进步强调了需要有效的预防策略.
- 目前的癌症预防方法不足,需要新的方法.
研究的目的:
- 为了识别能够重新激活视网膜母细胞瘤基因 (RB) 的天然饮料.产品.
- 为了评估这些饮料的抗炎,抗氧化和抗癌作用.
- 评估乳酸细菌对癌症特异性细胞因子产生和体内癌症模型的影响.
主要方法:
- 搜索了具有RB活性,抗炎和抗氧化特性的饮料.
- 研究了乳酸细菌对人类瘤亡因子相关的亡诱导配体 (TRAIL) 的作用.
- 给大鼠服用RB-reactivating果汁和乳酸细菌,以评估由氧甲诱导的异常密室焦点 (ACF) 和异常密室 (ACs) 的减少.
主要成果:
- 卡卡杜梅和石榴汁重新激活了RB,通过G1阶段停止抑制了人类结肠癌细胞的生长.
- 这些果汁表现出抗炎和抗氧化作用.
- 乳植物菌 pentosus S-PT84 增加了人类的 TRAIL 产量;含有 S-PT84 的果汁减少了老鼠的氧甲诱导的 ACF 和 ACs.
结论:
- 这项研究是第一个表明天然饮料可以重新激活视网膜母细胞瘤基因 (RB) 功能,这是致癌的关键抑制剂.
- 卡卡杜梅和石榴汁,含有乳酸细菌,通过抑制癌细胞生长和癌前病变,显示出预防癌症的潜力.
- 测试的果汁混合物代表了未来癌症预防策略的新候选人.
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