在巴西,与全身性胞三症相关的临床因素
Vanessa C R Magalhães1,2, Salene A Colombo3, Nalu T A Peres1
1Department of Microbiology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Mycoses
|September 25, 2023
概括
系统性运动三症在巴西正在增加,特别是在免疫能力强的个体中. 酒精摄入和糖尿病是艾滋病毒的关键危险因素,强调了早期诊断和治疗的必要性.
科学领域:
- 传染性疾病 传染性疾病
- 菌类学 菌类学是指菌类学.
- 流行病学 流行病学
背景情况:
- 系统性运动性三病,一种超出皮肤和淋巴结的器官感染,在巴西正在增加,即使在免疫能力良好的人群中也是如此.
- 现有的数据主要集中在人类免疫缺陷病毒 (HIV) 阳性患者身上,在了解其他人群的风险因素和临床模式方面存在差距.
- 这项研究调查了艾滋病毒阴性和艾滋病毒阳性患者全身性子三症的危险因素.
研究的目的:
- 在巴西队列中识别和分析与全身性运动三症相关的风险因素.
- 为了比较艾滋病毒阳性和艾滋病毒阴性患者与全身性运动三症之间的临床表现和结果.
- 阐明导致系统性胞三症严重疾病和死亡的因素.
主要方法:
- 在巴西进行了一项回顾性横截面研究,涉及80名在2014年至2021年期间被诊断患有子三症的患者.
- 使用后勤回归分析来检查疾病分类,临床表现和确定的风险因素之间的关联.
- 数据包括患者人口统计,艾滋病毒状况,临床表现和真菌学检查结果.
主要成果:
- 在80名患者中,有29名 (36.3%) 患有全身性运动三症. 所有人体免疫缺陷病毒 (HIV) 阳性患者都呈现了全身形式,与较高的死亡率相关 (p=.002).
- 摄入酒精 (p=.009) 和糖尿病 (p=.010) 与系统性疾病有显著联系. 酒精有利于肺部感染 (p=.013),而糖尿病与骨关节 (p=.009) 和眼部参与 (p=.033) 相关.
- 发烧 (p=.001) 和体重减轻 (p=.006) 与系统性运动三症相关. 脑膜干扰 (p=.001) 增加了死亡风险. 病变中的真菌结构预测了全身性疾病 (p=.017) 和死亡 (p=.002).
结论:
- 摄入酒精和糖尿病是系统性运动三症的重要危险因素,独立于艾滋病毒状况.
- 识别这些与艾滋病毒无关的风险因素对于及时诊断和有效管理严重的运动三症病例至关重要.
- 这项研究强调了在诊断和治疗系统性真菌感染时考虑常见的并发症的重要性.
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