中性粒细胞与淋巴细胞的比率与缺血性中风患者的中风进展和功能结果有关
Chongxi Xu1, Linrui Cai2,3,4, Tong Yi5
1Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Brain and behavior
|September 25, 2023
概括
中性粒细胞与淋巴细胞的比率 (NLR) 与中风进展和缺血性中风 (IS) 后的不良结果有关. 这种血液标志物可能有助于预测患者的康复,并为临床决策提供信息.
科学领域:
- 神经学 神经学
- 血液学 血液学 血液学
- 临床医学 临床医学
背景情况:
- 缺血性中风 (IS) 是导致残疾的主要原因.
- 预测中风进展和功能结果对于患者管理至关重要.
- 中性粒细胞与淋巴细胞的比率 (NLR) 是一个新兴的炎症标志物.
研究的目的:
- 在IS患者中调查NLR和中风进展 (SP) 之间的关联.
- 为了确定NLR是否能预测IS. 3个月后的功能结果.
- 评估NLR作为急性IS的预后指标的实用性.
主要方法:
- 对341名IS患者进行前性观察性研究.
- 在入院时测量的NLR水平.
- 在一周内评估中风进展情况和3个月后评估功能状态 (修改的兰金尺度).
- 使用多变量逻辑回归和ROC曲线分析.
主要成果:
- 16.4%的患者经历了中风进展.
- NLR和糖尿病独立地与SP和功能性结果差相关.
- 在NLR中,表现为功能性结果差的显著预测值 (AUC=0.6117,p=0.0032),最佳截止值为4.2139.
结论:
- 急性缺血性中风患者中风进展的发生率很高.
- NLR是中风进展和功能不良结果的独立预测因素.
- 在临床实践中,NLR可以作为IS的有价值和可访问的预后生物标志物.
相关概念视频
01:15Differentiation of Common Myeloid Progenitor Cells
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
01:21Structure and Function of Leukocytes
An adult in good health typically has between 4,500 and 11,000 leukocytes, or white blood cells, per microliter of blood, which constitutes about 1% of the total blood volume. Unlike red blood cells, white blood cells contain a nucleus and other cellular organelles but do not have hemoglobin. Most white blood cells reside in connective tissues, particularly in lymphatic organs such as the lymph nodes, with only a small fraction present in circulating blood.
White blood cells protect the body...
White blood cells protect the body...