普尔维纳定量敏感性测绘预测了帕金森病中视觉幻觉后深度脑刺激后的视觉幻觉
Keita Matsuura1, Yuichiro Ii2, Masayuki Maeda3
1Department of Neurology, Graduate School of Medicine, Mie University, Mie, Japan.
Brain and behavior
|September 25, 2023
概括
脉核 (PN) 的定量敏感度映射 (QSM) 可以预测帕金森氏症的视觉幻觉和认知衰退.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 医学物理 医学物理
背景情况:
- 之前的研究将低脉核 (PN) 强度与视觉幻觉和认知问题的敏感度加权成像联系起来.
- 帕金森病 (PD) 患者经常经历视觉幻觉和认知变化,特别是在深度大脑刺激 (DBS) 后.
研究的目的:
- 调查DBS接受PD患者PN的定量敏感度映射 (QSM) 变化.
- 为了确定QSM的PN敏感度值 (SV) 是否可以预测DBS后的视觉幻觉和认知改变.
主要方法:
- 在DBS手术前3个月内,对24名PD患者进行了QSM MRI扫描.
- 使用QSM评估PN SV,并分析了与认知变化和幻觉的关联.
- 在手术前立即评估认知功能,并在术后1年评估认知功能.
主要成果:
- 在随访期间,7名患者出现视觉幻觉.
- 与SV<0.045 ppm (1/15) (p = .0037) 相比,PN SV≥0.045 ppm的9名患者显示视觉幻觉的发病率更高 (6/9) .
结论:
- 通过QSM测量的PN SV可以作为PD患者在DBS后视觉幻觉的预测生物标志物.
- 较高的PN SV (>0.045 ppm) 可能表明DBS治疗后有视觉幻觉和认知恶化的风险.
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