胎儿减小和没有胎儿减小的四胎妊娠结果:丹麦国家队列研究 (2008-2018) 和与二双胞胎的比较
M K Rasmussen1,2, S E Kristensen1,2, C K Ekelund1,2
1Department of Obstetrics, Center for Fetal Medicine and Ultrasound, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
概括
在四胎妊娠中减少胎儿显著改善结果,减少早产和增加活产婴儿. 然而,减少四胞胎的结果与二二双胞胎的结果不匹配.
科学领域:
- 周围生理学 周围生理学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 生殖医学 生殖医学
背景情况:
- 四胎妊娠,特别是四四 (QCQA) 类型,具有相当大的风险.
- 胎儿减小是一种减轻与高阶倍数相关的风险的策略.
研究的目的:
- 为了比较减少与非减少的QCQA四胎妊娠的妊娠结果.
- 为了比较降低QCQA四胞胎与二二 (DCDA) 双胞胎怀孕的结果.
主要方法:
- 基于丹麦国家登记册的回顾性研究 (2008-2018).
- 包括33个QCQA四胞胎 (减少和非减少) 和9563个DCDA双胞胎怀孕.
- 主要结局:不良妊娠结果的组合;次要结局:妊娠年龄,活产婴儿,早产率,出生体重.
主要成果:
- 不良妊娠结局率在非减小的四胞胎中最高 (66.7%),在单胞胎中较低 (50%),在双胞胎中最低 (10.7%).
- 在被减少为双胞胎的四胞胎中,活生生的婴儿比例为91.1%,与未减少的DCDA双胞胎 (97.6%) 显著不同.
- 在28周,32周和37周之前的早产率在四胞胎减少到双胞胎的四胞胎中减少,与非减少的四胞胎相比.
结论:
- 在QCQA四胎中减少多胎妊娠改善了怀孕结果.
- 减少导致早产减少,活产婴儿比例更高.
- 四胞胎的怀孕结果减少到双胞胎没有达到DCDA双胞胎的水平.
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