持续认知困难与抑郁症之间的关联以及患有严重抑郁症的人的功能结果
F Matcham1,2, S K Simblett1, D Leightley1
1The Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Psychological medicine
|September 25, 2023
概括
大型抑郁症 (MDD) 中持续的认知困难与抑郁症严重程度和功能障碍的增加有关. 解决这些认知问题可能会改善患者的整体治疗结果.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 临床心理学 临床心理学
背景情况:
- 认知症状经常发生在抑郁症期间和之后.
- 关于认知功能的持久性及其与抑郁症和功能结果的关系的理解有限.
研究的目的:
- 研究患有重复性主要抑郁症 (MDD) 个人的自我报告和基于表现的认知功能的持久性.
- 为了确定持续认知困难与抑郁症严重程度和随着时间推移的功能障碍之间的关联.
主要方法:
- 一项为期两年的前性观察队列研究对623名患有复发性MDD的个体进行了二次分析.
- 基于应用程序的认知评估 (自我报告和基于绩效) 和经过验证的抑郁症,功能障碍和自尊的措施每3个月收集一次.
- 多层次建模用于分析参与者内部和参与者之间的认知功能,抑郁症和功能障碍的变化.
主要成果:
- 持续自我报告的认知困难与更高的抑郁症和功能障碍相关.
- 客观认知困难的高持久性 (>75%的时间点) 与低持久性 (<25%) 相比,与更大的抑郁症和功能障碍有显著的关联.
- 执行功能受损与整体功能恶化有关,处理速度减慢与抑郁症状恶化特别相关.
结论:
- 这项研究证实,MDD持续的认知困难与抑郁症严重程度和功能障碍的增加有关.
- 认知障碍可以作为关键指标和潜在的目标,用于增强MDD治疗干预措施.
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