在急性和康复期患者中长度抗SARS-CoV-2抗体免疫反应
Horacio Pérez-Juárez1,2, Angélica Serrano-Vázquez1, Héctor Godínez-Alvarez3
1Laboratorio de Inmunología, Unidad de Investigación en Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Frontiers in cellular and infection microbiology
|September 25, 2023
概括
这项研究检查了门诊患者的SARS-CoV-2抗体水平,发现疾病严重程度,BMI和并发症会影响IgM和IgG的持久性. 了解这些因素对于COVID-19免疫力评估至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 对影响SARS-CoV-2抗体动态和持久性的因素的理解有限.
- 全球努力评估COVID-19患者的早期免疫反应需要进一步调查影响变量.
研究的目的:
- 评估SARS-CoV-2感染的门诊患者的早期和康复期免疫力.
- 确定影响IgM和IgG抗体反应动态和持续性的因素.
主要方法:
- 使用SARS-CoV-2尖端蛋白RBD的ELISA对抗SARS-CoV-2IgM和IgG抗体的评估.
- 诊断后90天内墨西哥门诊患者的血清阳性分析.
- 评估抗体水平与性别,年龄,BMI,并发症和临床谱之间的关联.
主要成果:
- 患有中度和无症状疾病的个体在感染后90天显示出较低的IgM水平.
- 在90天内,在轻度至中度疾病的个体中观察到最高IgG水平.
- 回归树表明了IgM/IgG水平与临床谱,BMI和并发症之间的关系.
结论:
- COVID-19的临床谱影响了门诊患者抗SARS-CoV-2 IgM和IgG抗体的动态.
- 对SARS-CoV-2的抗体持久性可能与疾病严重程度,BMI和并发症的存在有关.
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