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生醇与安东基安素协同作用,诱导抗氧化活性in vitro

Amna Emhemed Abdurrahim^1,2, Vera C Mazurak¹, Lingyun Chen¹

¹Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, Canada.

Frontiers in nutrition

|September 25, 2023

概括

结合素和生醇可以增强细胞的抗氧化活性,为抗氧化压力和改善健康提供了有前途的方法. 这种协同效应可以促进身体的自然防御.

科学领域:

生物化学生物化学
细胞生物学细胞生物学
营养科学营养科学

背景情况:

自由基的氧化应激与慢性疾病有关.
饮食中的植物化学物质提供抗氧化剂保护,但其生物可用性较低.
提高植物化学品的生物可用性和有效性对于健康益处至关重要.

研究的目的:

为了研究结合安东素和生醇对细胞抗氧化反应的协同效应.
为了评估这种组合在氧化应激下对Caco-2细胞的影响.
评估功能性食品和营养保健品中安托西亚宁-生醇组合的潜力.

主要方法:

利用Caco-2细胞模型来模拟氧化应激条件.
评估了氨酸-生醇 (Ac-G) 组合的细胞抗氧化活性 (CAA) 和细胞保护作用.
测量了关键的抗氧化剂标志物,包括GPx和SOD酶活性,ROS生成,谷氨含量和脂质过氧化.

主要成果:

在 8:1 和 2:1 的比例下,观察到 Ac-G 组合的显著协同作用 (SE 值为 1.41 和 1.61).
协同作用的组合通过调节酶活动和减少氧化损伤来增强细胞抗氧化防御.
Ac-G组合有效地减少了活性氧物种 (ROS) 的产生,并抑制了脂质过氧化.

结论:

安索亚宁-生醇组合显示出强大的协同抗氧化剂和细胞保护作用.
这些组合支持内源性抗氧化系统,保护细胞免受氧化,并恢复氧化还原平衡.
Ac-G配方是克服低生物可用性和开发有效功能性食品的有希望的策略.

关键词:

它们是安托西安氨酸.细胞抗氧化剂活性细胞抗氧化剂活性.细胞保护作用细胞保护作用银杏子是什么银杏子是什么氧化应激是一种氧化应激.有协同效应的效应.

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