孕产妇的压力与母乳中蛋白质结合的氨基酸度较高有关
Hannah G Juncker1,2,3, Eva F G Naninck1,2, Britt J van Keulen2,3
1Brain Plasticity Group, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, Netherlands.
Frontiers in nutrition
|September 25, 2023
概括
母亲的压力会改变人乳中的氨基酸,这可能会影响婴儿的健康. 这项研究发现,压力较大的母亲的牛奶中蛋白质结合的氨基酸含量较高,这与皮质醇水平有关.
科学领域:
- 生殖生物学 生殖生物学
- 儿科 儿科 儿科
- 营养科学 营养科学
背景情况:
- 产后母亲的压力对婴儿的代谢和心理健康构成风险.
- 从母亲传给婴儿的压力传播机制尚未完全理解.
- 人母乳 (HM) 的成分随着母亲的压力而变化,但氨基酸 (AA) 的影响是未知的.
研究的目的:
- 为了研究母亲的压力和母乳的氨基酸组成之间的联系.
- 为了确定母亲的压力是否影响HM中的蛋白质结合和自由氨基酸.
主要方法:
- 观察性队列研究,比较高压力 (住院婴儿) 和控制 (健康婴儿) 组.
- 在分娩后10,17和24天收集HM样本.
- 通过问卷和皮质醇水平评估母亲的压力;使用液态染色学分析HM氨基酸.
主要成果:
- 在高压力组中,感知压力和HM皮质醇的增加.
- 受压力母亲的HM中蛋白质结合氨基酸的增加 (p=0.028).
- 与蛋白质结合的AA度与HM皮质醇正相关 (p=0.024);自由的AA没有显著差异.
结论:
- 产后母亲的压力与人乳氨基酸概况的改变有关.
- 在HM氨基酸的变化可能会调解压力传递给婴儿.
- 需要进一步的研究来了解对婴儿的发育影响.
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