抑制性temporo-parietal有效连接性与老年人明确记忆性能有关
Björn H Schott1,2,3,4, Joram Soch1,5, Jasmin M Kizilirmak1,6
1German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.
iScience
|September 25, 2023
概括
成功的记忆编码涉及到特定的大脑活动的变化,特别是在部和部区域. 衰老会影响这些记忆网络,老年人表现出对记忆形成至关重要的大脑区域之间的连接较弱.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 神经成像是一种神经成像.
背景情况:
- 显式记忆编码依赖于协调的大脑活动,包括部和部区域.
- 衰老与记忆功能的下降和大脑网络动态的改变有关.
研究的目的:
- 在新的视觉场景编码过程中,研究海马体,海马体外位区域 (PPA) 和前体之间的有效连接模式.
- 检查这些连接模式在年轻人和老年人之间有什么不同,以及与记忆性能有关.
主要方法:
- 功能磁共振成像 (fMRI) 数据的动态因果建模 (DCM).
- 对117名年轻成年人和两组老年人的大脑活动的分析 (N=141和N=148).
主要成果:
- 在成功编码的年轻人中观察到明显的PPA-to-hippocampus激活输入和PPA-to-precuneus抑制连接.
- 老年人表现出选择性减弱的抑制PPA-precuneus连接性,这与记忆性能有负相关性.
结论:
- 与年龄相关的记忆差异部分是由于改变了temporo-parietal新皮质连接.
- DCM分析揭示了显式内存编码和与年龄相关的衰退背后的关键网络动态.
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