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在具有不同祖先的跨种类酵母杂交体中基因组不稳定性的模式

Devin P Bendixsen¹, David Peris^2,3, Rike Stelkens¹

¹Population Genetics Division, Department of Zoology, Stockholm University, Stockholm, Sweden.

Frontiers in fungal biology

|September 25, 2023

概括

杂交酵母基因组表现出显著的不稳定性,在早期代人中常见的体积. 父母物种之间的基因组距离影响混合基因组相似性,为适应性进化提供了洞察力.

科学领域:

基因组学就是基因组学.
进化生物学进化生物学
酵母遗传学酵母遗传学

背景情况:

混合基因组经常显示基因组不稳定性,包括染色体重排,收益和损失.
这种基因组可塑性可以导致表型多样性和适应新的生态.
跨多种混合背景的基因组变异和不稳定性的普遍化模式仍然不清楚.

研究的目的:

分析跨物种Saccharomyces酵母杂交的基因组结构.
鉴定杂交物中的基因组变异和不稳定性的可概括模式和预测因素.
了解混合基因组在适应性进化中的作用.

主要方法:

对来自不同环境的204种跨物种的Saccharomyces酵母杂交菌进行分析.
同步映射以识别读取深度变化和形.
分享k-mer分析以评估基因组多样性和可变性.

主要成果:

体积是常见的 (44%),特别是在较小的染色体和早期代杂交物中.
基因组的多样性和变异性在混合物之间因原生物种而有所不同.
遗传上更遥远的交叉导致了更相似的混合基因组,可能是由于负面表观症.
线粒体基因组遗传通常跟随核基因组贡献,有显著的例外.

结论:

有可靠的基因组预测混合动力不稳定性的存在,以及交叉和环境特定的变异.
了解混合基因组动态对于理解适应性进化至关重要.
这项研究为预测混合基因组结果及其进化潜力提供了基础.

关键词:

这是一种Saccharomyces.没有积症.基因组的不稳定性混合化混合化混合化这是一个内进的进攻.失去了异性性的损失.酵母酵母是一种酵母.

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