术前静脉注射铁治疗 - 一项关于结直肠癌复发的队列研究
Magnus Ploug1, Niels Qvist2,3, Rasmus Kroijer4
1Department of Regional Health Research, University of Southern Denmark, Denmark.
Surgery open science
|September 25, 2023
概括
术前静脉注射铁治疗没有影响铁缺乏性贫血患者的结直肠癌复发率. 这项研究发现铁治疗与五年癌症复发风险之间没有关联.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 临床医学 临床医学
背景情况:
- 静脉注射 (IV) 输入 静脉注射 (IV) 输入 静脉注射 铁疗法对结肠直肠癌 (CRC) 恶性瘤潜力和免疫反应的影响受到辩论.
- 关于手术前静脉注射的临床数据有限. 铁对CRC复发的影响.
研究的目的:
- 调查手术前静脉注射药物之间的关联. 在患有缺铁性贫血的患者中,铁治疗和CRC复发.
主要方法:
- 对手术CRC患者患有缺铁性贫血的回顾性队列研究 (2013-2019).
- 在接受手术前静脉注射治疗的患者之间复发率的比较. 铁和那些没有铁的人.
- 生存分析,包括卡普兰-梅尔曲线和多变量竞争性风险分析,以关键临床因素进行调整.
主要成果:
- 分析包括125名患者 (89名静脉注射). 铁,36控制),具有可比的基线和外科特征.
- 随访时间中位数为4.74年 (静脉注射). 铁) 与5年 (对照) 相比.
- 五年无复发率为85% (静脉注射). 铁) 与82% (对照) 相比,差异不大. 多变量分析显示没有相关性 (HR 0.88;95% CI:0.31-2.51).
结论:
- 在手术前进行静脉注射. 铁治疗与缺乏铁的贫血CRC患者的五年癌症复发率无关.
相关概念视频
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
348
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
348
Drugs for Treatment of Ulcerative Colitis in IBD
164
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
164
Inflammatory Bowel Disease V: Surgical Management
164
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
164
Inflammatory Bowel Disease IV: Pharmacological Management
145
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
145
Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy
102
This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
102
Treatment Resistant Cancers
3.3K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K


