艾滋病毒中的金氨酸通路,脆弱和炎症
Shabiha Sultana1, Anthony Elengickal1, Husam Bensreti1
1Medical College of Georgia, Augusta University, Augusta, GA, United States.
Frontiers in immunology
|September 25, 2023
概括
基努瑞宁 (Kyn) 与衰老和艾滋病毒有关,影响骨和肌肉. 其生产途径的抑制剂可能为艾滋病毒感染的老年人与年龄相关的肌肉骨问题提供新的治疗方法.
科学领域:
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
- 老年学是一门学科.
背景情况:
- 氨酸 (Kyn) 是一种氨酸 (Trp) 代谢物,由氨酸二氧化酶1 (IDO1) 生产,氨酸二氧化酶1 (IDO1) 是由干扰素-诱导的酶.
- 基因水平随着年龄的增长而上升,并与神经退行,骨质疏松症和肉症有关.
- 艾滋病毒患者的Kyn水平增加,目前的疗法无法完全恢复IDO1活性.
研究的目的:
- 探索IDO1和阿里碳水化合物受体 (AhR) 抑制剂对肌肉骨健康的潜在重新用途.
- 研究Kyn和AhR激活在与年龄相关的肌肉骨衰退中的作用,特别是在HIV的背景下.
主要方法:
- 关于Kynurenine代谢,IDO1,AhR信号和与年龄有关的疾病的现有文献的综述.
- 对AhR激活对骨和肌肉细胞已知的影响的分析.
- 对IDO1和AhR抑制剂的当前临床试验的审查.
主要成果:
- kynurenine 作为一种内源性对基碳化合物受体 (AhR) 的激动剂.
- 激活AhR与肌肉缩,骨质细胞活性增加,骨质细胞功能减少和骨髓干细胞衰老有关.
- 目前,IDO1和AhR抑制剂正在进行癌症治疗的临床试验.
结论:
- kynurenine和AhR信号与与年龄相关的肌肉骨功能恶化有关.
- 重新使用IDO1和AhR抑制剂可能是改善肌肉骨健康的治疗策略,特别是在老年人群中,尤其是艾滋病毒感染者.
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