由口服必需无气体引起的儿童肺部感染:病例系列
Lai Zhijun1, Yang Wenhai1, Zeng Peibin1
1Department of Pediatric Intensive Care Unit, Dongguan Children's Hospital Affiliated to Guangdong Medical University, Dongguan, China.
由口腔无氧细菌引起的儿童肺炎是罕见但严重的. 下一代测序 (NGS) 在四个儿科病例中确定了口服无气体,导致有效的治疗和改善的结果.
科学领域:
- 儿童传染病 儿童传染病
- 微生物学 微生物学
- 肺部医学 肺部医学
背景情况:
- 肺炎在患有慢性疾病的儿童中很常见,如脑,营养不良和卧床儿童.
- 不良的口腔卫生和不充分的呼吸道保护是已知的肺炎的危险因素.
- 然而,很少报告由口服义务无气体引起的儿童肺炎.
研究的目的:
- 报告和分析四例由口服义务性无气体引起的儿科肺炎和.
- 突出诊断挑战和有效的治疗策略,为这种罕见的儿童疾病.
主要方法:
- 从儿科重症监护室 (PICU) 报告的一系列病例.
- 传统的细菌培养 (唾液,多液,血液) 的结果为负.
- 下一代测序 (NGS) 用于肺溢液和支气管洗液来识别病原体.
主要成果:
- NGS确定了口服义务性无气体,特别是*Parvimonas micra*和*Porphyromonas gingivalis*,作为致病剂.
- 患者接受了针对性抗生素治疗,包括皮佩拉西林塔佐巴克坦和美特罗尼达,导致临床改善.
- 这四名儿科患者都有显著的潜在健康问题和风险因素,包括长期的床上休息,严重的营养不良和口腔卫生不良.
结论:
- 在儿科肺炎中,特别是高风险儿童中,应考虑口服强制性无气体,即使它们更常见于老年患者.
- 在标准培养不显露时,NGS是快速识别病原体的宝贵工具.
- 强调口腔卫生对于预防儿童口腔无氧细菌性肺炎至关重要.
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