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患有炎症性肠道疾病的患者中痛风的患病率增加:一个基于人口的研究
Osama Hamid1, Khaled Alsabbagh Alchirazi1, Ahmed Eltelbany1
1Department of Hospital Medicine Cleveland Clinic Cleveland Ohio USA.
JGH open : an open access journal of gastroenterology and hepatology
|September 25, 2023
概括
炎症性肠病 (IBD) 与高风险的痛风有关,特别是克罗恩病. 肠切除进一步增加了这种风险,需要在IBD患者中进行痛风检查.
科学领域:
- 胃肠病学 胃肠病学
- 类风湿病学 类风湿病学
- 流行病学 流行病学
背景情况:
- 关节炎是已知的炎症性肠病 (IBD) 的肠外表现.
- 在IBD患者中观察到尿酸代谢的改变.
- IBD和痛风之间的关系需要进一步调查.
研究的目的:
- 调查炎症性肠病 (IBD) 和痛风之间的关联.
- 确定特定类型的IBD (克罗恩病和性结肠炎) 与痛风有不同的关联.
- 探索肠切除对IBD患者痛风风险的影响.
主要方法:
- 从1999年到2022年使用了多中心的美国医疗保健数据库 (Explorys Inc.)
- 确定的成年患者被诊断患有克罗恩病 (CD) 和性结肠炎 (UC).
- 使用多变量分析分析人口统计数据,IBD相关的关节炎,肠切除和痛风诊断.
主要成果:
- 在CD和痛风 (OR 1.68) 和UC和痛风 (OR 1.38) 之间发现了显著的关联.
- 痛风的患病率在UC患者中为4.3%,在CD患者中为5.61%.
- 肠切除与CD (OR 2.34) 和UC (OR 1.53) 患者的痛风风险增加有关.
结论:
- 炎症性肠病 (IBD) 与痛风有很强的联系.
- 克罗恩氏病与痛风的相关性比性结肠炎更高.
- 患有IBD和新发性关节炎的患者应对痛风进行评估,特别是如果他们经历了肠切除.
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