后调节促进中风后神经血管单元的恢复
Elga Esposito1,2, Ester Licastro1,3, Ornella Cuomo3
1Neuroprotection Research Laboratories, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States.
Frontiers in cellular neuroscience
|September 25, 2023
概括
缺血后调节通过增强来自星球细胞的脑衍生神经营养因子 (BDNF) 来促进中风恢复. 这种机制支持通过神经发生和血管发生在焦点脑缺血后的长期益处.
科学领域:
- 神经科学是一个神经科学.
- 脑卒中研究 脑卒中研究
- 细胞生物学 细胞生物学
背景情况:
- 缺血后调节通过减少心脏病发作,显示出急性中风恢复的前景.
- 临床转化受限于对短期结果的关注和不清楚的长期机制.
- 了解长期益处对于开发有效的中风疗法至关重要.
研究的目的:
- 阐明后调节的长期神经保护作用背后的机制.
- 为了研究星球细胞和脑衍生神经营养因子 (BDNF) 在后调节中介恢复中的作用.
- 探索后调节对神经生成和血管生成的影响.
主要方法:
- 雄性Sprague-Dawley大鼠经历过短暂的中脑动脉封闭 (MCAO),有或没有后调节.
- 心脏病发作量,神经发生和血管发生标志物在3天和2周后被评估.
- 酸被用于抑制星球细胞代谢,并进行了静脉内注射.
主要成果:
- 后调节显著增加了BDNF蛋白水平,特别是在星球细胞中.
- 用酸抑制天体细胞代谢消除了后调节的神经保护作用.
- 后调节依赖的神经发生和血管发生也被酸盐治疗废除.
结论:
- 在焦点大脑缺血症中,后调节的长期治疗效果包括促进神经发生和血管再造.
- 来自天体细胞的BDNF是这些后调节诱导的恢复机制的关键调解者.
- 这些发现突出了中风恢复的新治疗途径.
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