对合成生成的计算机断层扫描进行评估,用于跨的聚焦超声波手术
Han Liu1, Michelle K Sigona2,3, Thomas J Manuel2,3
1Vanderbilt University, Department of Computer Science, Nashville, Tennessee, United States.
Journal of medical imaging (Bellingham, Wash.)
|September 25, 2023
概括
来自MRI的合成CT图像使得跨的聚焦超声波 (tFUS) 能够在没有辐射暴露的情况下进行治疗规划. 这种方法为tFUS手术提供了与真实CT扫描可比的准确性.
科学领域:
- 医疗成像医学成像
- 生物物理学的生物物理.
- 神经学 神经学
背景情况:
- 穿焦点超声波 (tFUS) 是一种由MRI指导的非侵入性治疗方法.
- 目前,CT成像用于估计tFUS的头骨声学特性,使患者暴露在辐射中.
- 为了更安全的tFUS程序,需要一种无CT的声学参数估计方法.
研究的目的:
- 开发和评估一种合成MRICT图像的方法,用于TFUS治疗规划.
- 评估在tFUS计划中使用合成CT (sCT) 图像作为真正CT (rCT) 图像的替代品的可行性.
主要方法:
- 基于3D补丁的条件生成对抗网络被用来合成T1加权MRI的CT图像.
- 合成的CT (sCT) 图像与使用Kranion计划软件和k-Wave声学模拟的真实CT (rCT) 图像进行了比较.
- 模拟在三个条件下进行:没有偏差校正,基于克拉尼昂的相位校正和时间逆转相位校正.
主要成果:
- 头骨密度比率,厚度和sCT和rCT之间的活性元素的皮尔森相关系数高 (0.94,0.92,0.98).
- 在sCT和rCT之间模拟的峰值压力的差异在克拉尼翁相位校正 () 时是最小的.
- 在所有模拟案例中,峰值焦点位置之间的距离是一致的 ().
结论:
- 来自MRI的合成CT图像提供了可比的头骨声学特性和模拟指标,用于tFUS规划的真实CT图像.
- 这种使用MR合成CT图像的无CT方法可以减少接受tFUS的患者的辐射暴露.
- 开发的模型和源代码是公开可用的,用于进一步的研究和应用.
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