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在患有晚期心血管疾病的患者中,系统和局部血管炎症和动脉反应性氧物种生成

Joanna Sulicka-Grodzicka^1,2, Piotr Szczepaniak^3,4, Ewelina Jozefczuk^3,4

¹Department of Rheumatology and Immunology, Jagiellonian University Medical College, Krakow, Poland.

Frontiers in cardiovascular medicine

|September 25, 2023

概括

系统性炎症标记在晚期心血管疾病中不能可靠地表明局部血管炎症或氧化应激. 周围细胞因子水平和动脉壁细胞因子mRNA表达显示出明显的相关性,表明单独的生物过程.

科学领域:

心血管研究研究心血管研究
炎症生物学炎症生物学
血管医学血管医学

背景情况:

系统性炎症可以激活内皮,促进局部炎症,加速动脉样硬化.
了解全身和局部血管炎症之间的关系对于心血管疾病 (CVD) 管理至关重要.

研究的目的:

调查循环炎症细胞因子水平是否与人体内部乳腺动脉 (IMA) 和左前下降动脉 (LAD) 中的局部血管炎症和氧化应激相关.
评估晚期心血管疾病患者的全身和局部炎症标志物之间的关系.

主要方法:

从69名接受冠状动脉旁路移植 (CABG) 患者和17名接受心脏移植 (HTx) 患者的LAD中收集了IMA.
测量了瘤亡因子-α (TNF-α),干白素-6 (IL-6),干白素-1β (IL-1β) 和高灵敏性C反应蛋白 (hs-CRP) 的血水平.
评估了血管细胞因子mRNA表达,超氧化离子形成,以及动脉段中的血管反应性.

主要成果:

促炎性细胞因子mRNAs (TNF-α,IL-6,IL-1β) 在所有动脉段中都得到表达.
血细胞因子水平与血管细胞因子mRNA表达在IMA或LAD中没有相关性.
系统性或局部炎症标志物与超氧化物生成无相关性;然而,循环中的IL-1β与IMA放松有负相关性.

结论:

在晚期心血管疾病中,外周炎性细胞因子测量可能不准确地反映局部血管炎症或氧化应激.
虽然全身和局部炎症标志物在各自的隔间内显示内部相关性,但它们在隔间之间没有相关性.
研究结果表明,在晚期心血管疾病中,不同的炎症途径在系统上和动脉壁内运行.

关键词:

心血管疾病心血管疾病细胞因子细胞因子这是一个hs-CRP.这是一种炎症炎症炎症炎症.氧化应激是一种氧化应激.这是一种超氧化物.

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