在心力衰竭中,klotho和FGF23的短期变化与减少喷射分数-DAPA-VO研究的子研究2
Carmen Mora-Fernández1, Adora Pérez2, Anna Mollar2,3
1Research Unit, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain.
Frontiers in cardiovascular medicine
|September 25, 2023
概括
在1个月后,达帕格利弗洛辛治疗显著增加了klotho水平,并降低了纤维细胞生长因子23 (FGF-23) 在心力衰竭患者中.
科学领域:
- 心血管医学 心血管医学
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 克洛托和纤维细胞生长因子23 (FGF-23) 途径在心血管疾病中起作用.
- 减少喷射分数 (HFrEF) 的心力衰竭是一种重要的心血管疾病.
- 了解新型治疗对这种途径的影响对于HFrEF管理至关重要.
研究的目的:
- 评估达帕格利弗洛辛对稳定HFrEF患者的克洛托和FGF-23水平的影响.
- 评估在达帕格利弗洛辛 (Dapagliflozin) 后这些生物标志物的短期变化.
主要方法:
- 一个DAPA-VO2临床试验的副研究,涉及29名HFrEF患者.
- 患者随机分配,接受达帕格利弗洛辛或安慰剂.
- 在基线和30天后使用ELISA套件测量Klotho和FGF-23水平.
主要成果:
- 达帕格利弗洛辛治疗导致中位克洛托水平显著增加 (Δ+29.5 pg/ml,p=0.009).
- 观察到达帕格利弗洛辛 (Δ-4.6 RU/ml,p=0.051) 的FGF-23水平下降的趋势.
- 推理分析证实了日志-klotho (p=0.011) 的显著增加和日志-FGF-23 (p=0.040) 的下降.
结论:
- 达帕格利弗洛辛治疗导致HFrEF患者的克洛托水平短期增加.
- 达帕格利弗洛辛治疗与HFrEF患者的FGF-23水平下降有关.
- 这些发现表明,HFrEF中的达帕格利弗洛辛对克洛托-FGF23轴的潜在有益调节.
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