新旧定义的HIV晚期诊断;来自土耳其地区医院的数据
Aslıhan Candevir1, Ferit Kuscu1, Behice Kurtaran1
1Infectious Diseases, Çukurova University, Adana, Türkiye.
International journal of general medicine
|September 25, 2023
概括
晚期诊断艾滋病毒仍然是一个挑战,影响患者的治疗结果和医疗保健成本. 这项在土耳其的研究发现,老年和与大流行有关的服务中断是晚期艾滋病毒诊断的风险因素,导致预后较差.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 人类免疫缺陷病毒 (HIV) 护理的延迟呈现是一个重大挑战,有助于增加发病率,死亡率和社会成本.
- 了解晚期艾滋病毒诊断的发生率和特征对于制定有效的公共卫生战略至关重要.
研究的目的:
- 确定土耳其艾滋病毒患者晚期诊断 (LD) 和晚期疾病 (AD) 的发生率.
- 为了识别与晚期艾滋病毒诊断相关的患者特征.
- 评估COVID-19大流行对晚期艾滋病毒诊断率的影响.
主要方法:
- 对1998年至2023年期间入院的794名先前未接受治疗的艾滋病毒患者进行了回顾性分析,并进行了至少一年的随访.
- 晚期诊断 (LD) 定义为CD4计数<350细胞/毫升或艾滋病定义事件,晚期疾病 (AD) 定义为CD4计数<200细胞/毫升或艾滋病定义事件.
- 从"晚期"分类中排除了最近有感染证据的患者.
主要成果:
- 使用新的定义,47.2%的患者被诊断为晚期艾滋病毒感染 (LD).
- 在COVID-19大流行期间,与大流行前时期相比,LD (55.8%) 和AD (30.1%) 率的显著增加被观察到.
- 患有LD的患者年龄较大,病毒学反应较差,死亡率较高 (4.8%对1.2%),存活时间较短.
结论:
- 晚期艾滋病毒诊断与预后较差有关,年龄较大和与流行病相关的卫生服务中断被确定为风险因素.
- 建议进行多中心研究,以调查错失的机会和晚期艾滋病毒诊断的特定区域风险因素.
- 加强风险人群的查,提高意识,以及持续倡导艾滋病毒检测,即使在危机期间也是必不可少的.
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