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从天然衍生的脂胺中制备质悬浮物的可行性

Søren Kristensen¹, Khadeija Hassan¹, Nadia Skarnager Andersen¹

¹Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Odense, Denmark.

Frontiers in medical technology

|September 25, 2023

概括

大豆酸胺 (SPS) 可以形成稳定的质颗粒,类似于二氧化酸胺 (DOPS) 质,特别是高纯度的SPS. 这证明了基于脂质的药物输送系统的可行替代方案.

科学领域:

生物材料科学生物材料科学
药物输送系统药物输送系统
脂质纳米技术脂质纳米技术

背景情况:

状物是稳定的,脱水的脂双层颗粒,为药物配方提供优势,包括改善口服生物可用性和持续的腹腔释放.
脂素 (PS) 是用于质制备的关键负电荷脂,二氧化酸酸 (DOPS) 被认为是标准的.

研究的目的:

调查使用不同纯度级别的豆乙衍生型酸 (SPS) 制备质悬浮物的可行性.
为了比较SPS衍生质与已建立的DOPS质.
为了评估SPS纯度和离子度对状细胞结构和组织的影响.

主要方法:

从大豆酸胺素 (SPS) 制备质悬浮液,其纯度从53%到96%以上.
与二氧化-氨酸-酸氨酸 (DOPS) 化物进行比较.
使用电子显微镜,小角度X射线衍射 (SAXD) 和劳丹泛极化 (GP) 分析进行了表征.
评估计算机控制的混合和透析方法用于制备.

主要成果:

从高纯度的SPS (≥96%) 成功制备了与DOPS质可比的内部脂质结构的质悬浮液.
较低纯度的SPS也产生了高度脱水和有组织的板状结构,尽管粒子形态不那么明确.
最佳的状筒形成需要更高的离子度与较低纯度的SPS.
通过透析从大豆PS盐直接制备状或状颗粒被证明是可行的.

结论:

豆酸胺 (SPS) 是DOPS的可行的替代品,用于制备质悬浮液,特别是当达到高头组纯度时.
从SPS衍生出的质体表现出强大的脂质组织和脱水,适合药物输送应用.
制备方法,包括离子度和SPS的纯度,影响最终的粒子形态和结构.

关键词:

化物化物药物输送是药物输送的过程.电子显微镜的电子显微镜脂质配方中的脂质配方酸盐酸氨酸是一种酸.物理化学特征的表征.

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