迈向对口腔患者进行袋式诊断:利用激光诱导的石墨烯传感器的多功能性
Conor McCann1, Victoria Gilpin1, Cameron Scott1
1School of Engineering, Ulster University, Belfast, Northern Ireland.
概括
一个新的3D打印的石墨烯传感器可以监测静脉口腔液的pH值在口腔口袋内. 这种生物相容的传感器使用利博夫拉作为氧化还原探针,在模拟条件下提供准确可靠的pH测量.
科学领域:
- 材料科学 材料科学 材料科学
- 电化学 电化学 电化学
- 生物医学工程 生物医学工程
背景情况:
- 胃口袋的管理需要定期监测结肠口腔液的pH值.
- 现有的pH监测方法往往不方便或侵入性.
- 为了改善患者护理,需要开发集成的一次性传感器.
研究的目的:
- 开发和描述一个3D打印的石墨烯传感器,用于直接集成到口腔口袋.
- 为了评估传感器的性能,定期监测静脉管液的pH值.
- 为了评估传感器的准确性和可靠性在模拟的骨干切开条件下.
主要方法:
- 在聚胺薄膜上使用激光诱导的石墨烯制造一个两电极传感器.
- 使用电子显微镜,拉曼光谱和形状测量进行表征.
- 电化学分析与循环和正方形波电压测量,使用 riboflavin 作为氧化还原探针.
- 在模拟的结节管液发酵模型中的性能评估.
主要成果:
- 石墨烯传感器显示线性pH响应为3-8 (43 mV/pH).
- рибофлавин 探针显示可逆行为与最小的漏.
- 传感器在复杂的细菌介质中提供了明确的信号.
- 在模拟的静脉切开液中测量的pH值与商业探头 (pH值5.3至3.66) 有很好的一致性.
结论:
- 一个3D打印的石墨烯传感器适合直接纳入口腔口袋.
- 该传感器可以可靠地定期监测结节管液的pH值.
- 这项技术有可能改善口腔护理和患者的治疗结果.
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