亚洲人群中精神分裂症的长效注射抗精神病治疗:一个范围审查
Ning Ma1,2,3, Lei Zhang4, Wufang Zhang1,2,3
1Peking University Sixth Hospital, Beijing, People's Republic of China.
Neuropsychiatric disease and treatment
|September 25, 2023
概括
在亚洲精神分裂症患者中,长效注射抗精神病药 (LAI) 的疗效和安全性与口服抗精神病药物相比较. 此外,LAI还可以提高治疗坚持度,降低复发率.
科学领域:
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 在亚洲精神分裂症患者中,长效注射抗精神病药物 (LAI) 的比较益处尚不清楚.
- 现有的关于LAI有效性,安全性,遵守性和医疗保健资源利用率的证据在这个人群中是不一致的.
研究的目的:
- 在过去十年中,对亚洲精神分裂症患者的LAI抗精神病药物进行综合证据.
- 提供LAI有效性,安全性,坚持性,患者态度和医疗资源利用情况的概述.
主要方法:
- 在过去十年中发表的46项研究的范围审查.
- 在六个电子数据库 (CNKI,Wanfang,PubMed,Embase,CINAHL,PsycArticles) 进行系统搜索.
- 包括的研究包括队列研究,单臂试验,RCT,镜像研究,横截面研究和受控临床试验.
主要成果:
- 帕利佩里棕酸盐和Risperidone LAI是最受研究的药物.
- 治疗方法的有效性和安全性与口服抗精神病药物 (OAMs) 相当.
- 地方医疗机构的复发/住院率较低,执法能力更强,医疗资源利用率降低 (住院时间,门诊).
结论:
- 在亚洲精神分裂症患者中,LAI抗精神病药的疗效和安全性与OAM相比较.
- 治疗方法与改善治疗坚持和减少复发率有关.
- 需要进一步的研究,以探索在特定的亚洲人群和环境中的LAI表现.
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