低酸血症和高酸血症都与败血症患者的死亡率增加有关
Zheng Liu1, Teng Li1, Yihan Du1
1The First Affiliated Hospital of China Medical University, Shenyang, China.
Frontiers in nephrology
|September 25, 2023
概括
低血清酸盐水平和高血清酸盐水平都会增加败血症患者的死亡风险. 这些条件,低酸血和高酸血,是死于败血症的独立风险因素.
科学领域:
- 临界护理医学 临界护理医学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 生物化学 生物化学
背景情况:
- 败血症是一种危及生命的器官功能障碍,是由宿主对感染的反应失调引起的.
- 血清酸盐水平在细胞代谢和整体生理功能中起着至关重要的作用.
- 在重症患者中经常观察到改变的酸盐平衡,包括低酸盐血和高酸盐血.
研究的目的:
- 为了研究血清酸盐水平与败血症患者的预后之间的关联.
- 确定低酸血症或高酸血症是否是败血症患者死亡的独立风险因素.
- 为了在患有和没有慢性病的患者中单独探索这些关系.
主要方法:
- 对包括败血病患者在内的公共数据库的回顾性分析.
- 根据患有慢性病的情况,将患者划分为子组.
- 倾向性得分匹配分析用于比较患有异常酸盐水平 (低酸盐血,高酸盐血) 和正常酸盐血的患者之间的结果.
- 利用Kaplan-Meier方法和多变量后勤/Cox回归来进行生存和死亡率分析.
主要成果:
- 低酸血和高酸血都与增加的住院死亡率,28天死亡率和感染性休克风险显著相关.
- 患有高酸血症的患者也显示了更高的替代疗法和急性功能衰竭率.
- 低血是没有慢性病的败血症患者死亡的独立风险因素,而高血是所有败血症患者死亡的独立风险因素.
结论:
- 低酸血症和高酸血症都是导致败血症患者死亡率增加的重要独立危险因素.
- 不正常的血清酸盐水平,无论是太低还是太高,预示着败血症的预后更差.
- 血清酸盐水平的监测和管理可能对改善败血症的结果至关重要.
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