近接性免疫-上皮原体相互作用驱动COVID-19后的慢性组织后续
Harish Narasimhan1,2,3, In Su Cheon1,2, Wei Qian1,2
1Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, VA 22908, USA.
COVID-19 (PASC) 后急性后续包括由免疫细胞与上皮原体相互作用驱动的肺修复受损. 针对这些相互作用的疗法可以在病毒性肺炎后恢复肺功能.
科学领域:
- 肺部病理学 肺部病理学
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 后急性后续COVID-19 (PASC) 带来了重大的长期健康挑战,持续炎症和器官恢复不良背后的机制尚不清楚.
- 呼吸道PASC的特点是肺功能异常和肺纤维化,需要进一步研究其潜在的病理生理学.
结论:
- 失调的免疫上皮原体位驱动呼吸道PASC.
- 感染后IFN-γ,TNF或IL-1β的治疗中和可以改善气泡膜再生和肺功能.
- 突出了病毒后纤维化疾病的潜在晚期治疗策略.
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