减少干扰素-γELISpot的败血症患者的不良长期结果和免疫抑制的内型:一个多中心,前性观察性研究
medRxiv : the preprint server for health sciences
|September 25, 2023
概括
一种新的干扰素马 (IFN-γ) ELISpot测定准确预测败血症死亡风险,并识别免疫抑制患者. 这种功能性免疫反应比毒症患者分层的传统生物标志物提供了更高的精度.
科学领域:
- 免疫学 免疫学 免疫学
- 关键护理医学 关键护理医学
- 生物标志物发现发现
背景情况:
- 败血症需要精确的风险分层来进行有效的治疗.
- 目前的方法依赖于蛋白质/mRNA生物标志物或静态细胞表型.
- 功能性免疫反应可能在预测败血症结果方面提供更好的准确性.
结论:
- 全血IFN-γ ELISpot测定可以识别高死亡风险的败血症患者.
- 这种测试也可以识别免疫抑制性败血症患者.
- 功能性免疫试验为败血症患者的内型和风险分层提供了一个精确的工具.
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