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Updated: Jul 15, 2025

Whole-Brain Single-Cell Imaging and Analysis of Intact Neonatal Mouse Brains Using MRI, Tissue Clearing, and Light-Sheet Microscopy
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发展小鼠大脑 共同的坐标框架

Fae A Kronman1, Josephine K Liwang1, Rebecca Betty1

  • 1Department of Neural and Behavioral Sciences, College of Medicine, The Pennsylvania State University, Hershey, PA.

bioRxiv : the preprint server for biology
|September 25, 2023
PubMed
概括
此摘要是机器生成的。

一个新的3D发展共同坐标框架 (DevCCF) 为小鼠开发提供了标准的参考大脑. 这种资源使大规模的数据集成能够全面了解大脑发育.

科学领域:

  • 神经科学是一个神经科学.
  • 发展生物学 发展生物学
  • 生物信息学是一种生物信息学.
关键词:
GABA神经元中的GABA神经元.解剖学细分的解剖学细分.大脑发育大脑发育的大脑发育共同的协调框架 (CCF)多式联运注册是多式联运注册.参考地图是参考地图.

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背景情况:

  • 标准的3D参考大脑对于大脑研究和数据互操作性至关重要.
  • 缺乏标准化的3D地图集来开发小鼠大脑,这限制了理解大脑发育的进展.

结论:

  • DevCCF是一个公开可访问的资源,用于整合多样化的发育神经科学数据集.
  • 通过标准化的空间引用,促进对小鼠大脑发育的全面理解.
  • 能够在发育神经生物学和比较研究中进行先进的研究.