感染后:对病原体和人类非传染性疾病的调查
Michael Lape1,2,3, Daniel Schnell2, Sreeja Parameswaran3,4
1Department of Biomedical Informatics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
medRxiv : the preprint server for health sciences
|September 25, 2023
概括
这项研究使用大型数据集调查了病原体与非传染性疾病 (NCD) 的联系. 研究人员发现了15种与96种疾病相关的病原体,其中包括人类细胞巨核病毒和性结肠炎之间的有争议的联系.
科学领域:
- 传染病流行病学 传染病流行病学
- 基因组学就是基因组学.
- 非传染性疾病研究的研究.
背景情况:
- 病原体和传染病之间的确立联系众多.
- 病原体和非传染性疾病 (NCD) 之间的联系不太清楚.
- 调查这些联系对于公共卫生至关重要.
研究的目的:
- 系统地调查病原体与各种疾病之间的关联,重点关注非传染性疾病.
- 通过使用大规模的现实世界数据,识别和验证病原体-疾病对.
- 探索感染和慢性疾病之间的潜在机械联系.
主要方法:
- 利用英国生物银行和TriNetX的数据进行了全面的调查.
- 评估了20种病原体和426种疾病的疾病状况和感染史代理之间的关联.
- 采用直角分析来验证特定的病原体与疾病的联系,包括基因表达和遗传风险信号.
主要成果:
- 确定了206种在两个队列中复制的病原体-疾病对.
- 已确认的已知关联,如Helicobacter pylori与胃肠道疾病和爱斯坦-巴尔病毒与多发性硬化和狼.
- 发现15种病原体与96种不同的疾病存在关联的证据,特别是人类细胞巨血病毒 (CMV) 和性结肠炎 (UC) 之间的联系.
结论:
- 这项研究为了解病原体在非传染性疾病中的作用提供了基础.
- 通过基因表达和遗传分析验证了CMV和UC之间的有争议的关联.
- 强调病原体可能有助于非传染性疾病的发展或进展.
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