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Updated: Jul 24, 2026

Assessment of Immunologically Relevant Dynamic Tertiary Structural Features of the HIV-1 V3 Loop Crown R2 Sequence by ab initio Folding
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Assessment of Immunologically Relevant Dynamic Tertiary Structural Features of the HIV-1 V3 Loop Crown R2 Sequence by ab initio Folding

Published on: September 15, 2010

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艾滋病毒-1包膜糖蛋白的形态灵活性调节了对广泛中和抗体的传递/创始人敏感性

Durgadevi Parthasarathy1,2, Karunakar Reddy Pothula3,2, Kim-Marie A Dam4

  • 1Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.

bioRxiv : the preprint server for biology
|September 25, 2023
PubMed
概括

许多HIV-1菌株具有不完全封闭的包膜糖蛋白 (Envs),使它们易受针对开放状态的抗体的攻击. 这一发现影响了用于预防和治疗艾滋病毒的广泛中和抗体 (bnAbs) 的设计.

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