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癌细胞中的Acod1表达促进了通过生成抑制性的免疫逃避

James H Schofield1, Joseph Longo2, Ryan D Sheldon3

  • 1Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556 USA.

bioRxiv : the preprint server for biology
|September 25, 2023
PubMed
概括

免疫检查点阻塞疗法受到免疫抑制瘤微环境的限制. 在癌细胞中准酸脱碳酶 (Acod1) 可以通过防止CD8+ T细胞抑制来使瘤对PD-1阻塞敏感.

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