相关实验视频

Updated: Jul 15, 2025

Functional Reconstitution and Channel Activity Measurements of Purified Wildtype and Mutant CFTR Protein
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Functional Reconstitution and Channel Activity Measurements of Purified Wildtype and Mutant CFTR Protein

Published on: March 9, 2015

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小分子校正器通过稳定连续折叠状态来使CFTR-F508del从ERAD转移

Celeste Riepe1, Magda Wąchalska1, Kirandeep K Deol2,3,4

  • 1Department of Biology, Stanford University, Stanford, CA, USA 94305.

bioRxiv : the preprint server for biology
|September 25, 2023
PubMed
概括

囊性纤维化 (CF) 治疗向囊性纤维化跨膜导电性调节器 (CFTR) 蛋白中的F508del突变. 这项研究确定了参与CFTR-F508del降解的关键分子机制,揭示了校正剂如何改善CFTR蛋白水平.

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Analysis of Protein Folding, Transport, and Degradation in Living Cells by Radioactive Pulse Chase08:59

Analysis of Protein Folding, Transport, and Degradation in Living Cells by Radioactive Pulse Chase

Published on: February 12, 2019

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