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相关概念视频

Atherosclerosis III: Management01:26

Atherosclerosis III: Management

11
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
11
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

9
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
9
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

11
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
11
Atherosclerosis IV: Nursing Management01:23

Atherosclerosis IV: Nursing Management

21
Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
21
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

20
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
20
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

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Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
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相关实验视频

Updated: Jul 15, 2025

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
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Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

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开发和实施一个集成的临床前动脉样硬化数据库.

Rachel Xiang1, Yihua Wang1, Megan M Shuey2

  • 1Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA.

bioRxiv : the preprint server for biology
|September 25, 2023
PubMed
概括

从临床前动脉样硬化小鼠模型中整合数据可以改善基础科学发现的转化为临床进展. 这种方法可以全面分析疾病机制中的基因功能.

科学领域:

  • 生物医学研究的研究.
  • 翻译科学是一门翻译科学.
  • 心血管研究的心血管研究.

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Quantification of Atherosclerosis in Mice
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Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus

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相关实验视频

Last Updated: Jul 15, 2025

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
09:06

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

8.3K
Quantification of Atherosclerosis in Mice
06:59

Quantification of Atherosclerosis in Mice

Published on: June 12, 2019

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Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus
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背景情况:

  • 临床前动物模型对于理解人类疾病机制至关重要,产生了大量的出版物,但临床翻译有限.
  • 对现有研究的综合分析提供了一个有前途的策略,以提高医学中的翻译成功.

结论:

  • 开发的方法和软件可以应用于各种人类疾病的其他临床前模型.
  • 未来的应用包括基于斑块病理,细胞类型或性别分析子数据集.
  • 这种综合方法旨在释放临床前数据的全部潜力,以获得机械洞察力和临床转化.