跨越物质使用障碍的反社会人格障碍的关联模式
medRxiv : the preprint server for health sciences
|September 25, 2023
概括
反社会人格障碍 (ASPD) 与酒精,大麻和烟草使用障碍 (SUD) 有关. "危险使用"标准在SUD中与ASPD强烈相关,但只有TUD危险使用和可卡因戒断尝试独立地保持显著.
科学领域:
- 精神病学和行为科学 精神病学和行为科学
- 成 药物 药物 药物 药物
- 临床心理学 临床心理学
背景情况:
- 在有物质使用障碍 (SUD) 的个人中观察到反社会人格障碍 (ASPD) 的高患病率.
- 对ASPD,SUD严重程度和诊断标准之间的特定关联的理解有限.
- 需要对ASPD和各种SUD的同时发生模式进行详细的调查.
研究的目的:
- 调查ASPD与五个DSM-5SUD诊断之间的关联:酒精,大麻,可卡因,阿片类药物和烟草使用障碍.
- 检查ASPD与这些SUD (轻度,中度,严重) 的严重程度之间的关系.
- 确定与ASPD显著相关的特定SUD诊断标准.
主要方法:
- 在1660名ASPD患者和6640名匹配对照人群的样本上利用了通用线性回归.
- 评估了与AUD,CanUD,CocUD,OUD和TUD诊断的关联及其严重程度.
- 分析了与ASPD相关的每个SUD的个人DSM-5诊断标准.
主要成果:
- ASPD与酒精使用障碍 (AUD),大麻使用障碍 (CanUD) 和烟草使用障碍 (TUD) 的诊断和严重程度显著相关.
- "危险使用"标准显示,在所有研究的SUD中,与ASPD的关联最强.
- 独立地,ASPD与TUD"危险使用"和CocUD"试图戒烟" (反向关系) 有显著的关联.
结论:
- ASPD与特定的SUD诊断和严重程度有关,特别是AUD,CanUD和TUD.
- "危险使用"标准是ASPD在多种物质使用障碍中的关键指标.
- 了解这些特定的关联,就像试图戒断可卡因和ASPD之间的反向联系一样,为多重物质成和心理健康提供了新的见解.
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