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Updated: Jul 15, 2025

Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration
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Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration

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结构变异检测和整个基因组序列数据的关联分析来自16,905个阿尔茨海默氏症疾病测序项目对象

Hui Wang1,2, Beth A Dombroski1,2, Po-Liang Cheng1,2

  • 1Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, PA 19104, USA.

medRxiv : the preprint server for health sciences
|September 25, 2023
PubMed
概括

结构变异 (SVs) 显著影响阿尔茨海默病 (AD) 遗传学. 这项研究发现,在AD病例中,删除和重复的负担更高,突出显示SVs是AD风险的关键贡献者.

关键词:
阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.副本数量变化的变化结构变化的结构变化.

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