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Updated: Jul 15, 2025

Generation of Dispersed Presomitic Mesoderm Cell Cultures for Imaging of the Zebrafish Segmentation Clock in Single Cells
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解开生殖系和soma中的钟形突变的来源

Natanael Spisak1, Marc de Manuel1, William Milligan1

  • 1Department of Biological Sciences, Columbia University, New York, United States.

bioRxiv : the preprint server for biology
|September 25, 2023
PubMed
概括

两个无处不在的突变特征,SBS特征1和SBS特征5,显示了与年龄相关的积累. SBS签名1与细胞分裂率有关,而SBS签名5与DNA修复错误有关,揭示了这些"钟形"突变的独特起源.

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