机器学习确定了在固体瘤中差异化治疗的策略
bioRxiv : the preprint server for biology
|September 25, 2023
概括
机器学习通过恢复CDX2表达来准确地准结直肠癌中的癌症干细胞 (CSC). 这种方法显示出降低50%的死亡率和复发风险的潜力,推进了个性化医疗.
科学领域:
- 在瘤学瘤学.
- 计算生物学 计算生物学
- 基因组学就是基因组学.
背景情况:
- 固体瘤分化疗法受到异质性的限制,阻碍了计算方法.
- 结肠直肠癌 (CRCs) 作为一个模型来展示针对癌症干细胞 (CSCs) 的机器学习 (ML) 策略.
研究的目的:
- 开发和验证基于ML的方法来跟踪,区分和选择性地针对CRC中的CSC.
- 确定治疗点和恢复CDX2表达的策略,CDX2表达是激进CRC中丢失的分化结肠细胞的关键标志物.
主要方法:
- 使用广泛的人类和小鼠基因表达数据构建和验证了一个转录基因网络.
- ML算法优先考虑治疗目标和策略,重点关注CDX2再表达.
- 一种针对CDX2的临床级药物在体外,体外异种移植和患者衍生器官 (PDO) 进行了试验.
主要成果:
- 该药物成功诱导了CDX2表达和密码分化,在所有模型中证明了对CDX2-阴性细胞的选择性细胞毒性.
- 在PDO的多变量分析证实了治疗疗效与CDX2生物标志物之间的联系.
- 在约1700个CRC中验证的50个基因治疗反应的签名表明,死亡率/复发风险的潜在降低约为50%.
结论:
- ML方法精确地针对CSC,客观地评估临床影响.
- 这项研究说明了ML在为个性化癌症医学产生临床见解方面的实用性.
- CDX2恢复疗法对改善结肠直肠癌患者的治疗结果显示出希望.
更多相关视频
04:09Predicting Treatment Response to Image-Guided Therapies Using Machine Learning: An Example for Trans-Arterial Treatment of Hepatocellular Carcinoma
Published on: October 10, 2018
8.3K
07:15Machine Learning Algorithms for Early Detection of Bone Metastases in an Experimental Rat Model
Published on: August 16, 2020
6.8K
相关概念视频
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Tumor Immunotherapy
551
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
551
Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
