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Updated: Aug 16, 2026

A Neuronal and Astrocyte Co-Culture Assay for High Content Analysis of Neurotoxicity
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对亨廷顿病的多OMIC分析揭示了神经保护性天体细胞状态

Fahad Paryani1, Ji-Sun Kwon2, Chris W Ng3

  • 1Department of Neurology, Columbia University Irving Medical Center.

bioRxiv : the preprint server for biology
|September 25, 2023
PubMed
概括

亨廷顿病 (HD) 涉及神经元损失. 这项研究确定了一种保护性天体细胞表现型,表达metallothioneins,缓冲谷氨酸和增强微质活动,提供潜在的神经保护在HD.

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Huntington Disease l: Introduction01:21

Huntington Disease l: Introduction

Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show reduced penetrance,...