强大的环境记忆被实验进化在静态和波动的环境中揭示出来
Clare I Abreu1, Shaili Mathur1, Dmitri A Petrov1
1Department of Biology, Stanford University; Stanford CA, USA.
bioRxiv : the preprint server for biology
|September 25, 2023
概括
环境波动对进化产生重大影响,导致酵母种群的非添加性适应性和"环境记忆". 这表明静态环境变异可以预测动态条件下的健康状况.
科学领域:
- 进化生物学 进化生物学
- 微生物进化 微生物进化
- 人口遗传学 人口遗传学
背景情况:
- 在稳定的实验室环境中的进化通常涉及具有重大影响的突变.
- 自然环境的波动,带来了不存在于静态条件下的挑战.
- 在波动的环境中预测适应性假设静态适应性的时间平均值,但过渡会导致偏差.
研究的目的:
- 在波动的环境中调查预期适应性的偏差.
- 为了确定环境记忆是否影响健身.
- 探索驱动酵母进化中这些效应的机制.
主要方法:
- 在静态和波动条件下追踪成千上万条条码酵母血统.
- 在15个环境中对900个孤立突变体进行了聚合健康测试.
- 使用数学建模和全基因组测序.
主要成果:
- 在波动的环境中的适应性经常偏离静态预期,表明非增强性.
- 观察到环境记忆,其中一个条件的适应性取决于先前的环境.
- 静态环境中的高适应性变异与环境记忆效应相关.
结论:
- 环境波动对进化轨迹和健康有重大影响.
- 适应性非附加性和环境记忆是在波动的环境中常见的现象.
- 静态环境中的变量可以作为动态条件下健身影响的预测指标.
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