同时使用COVID-19和流感疫苗可以增强Spike特异性抗体反应
Susanna E Barouch1, Taras M Chicz1, Ross Blanc1
1Ragon Institute of MGH, MIT, and Harvard.
bioRxiv : the preprint server for biology
|September 25, 2023
概括
将双价COVID-19增剂和流感疫苗一起使用可能会增强抗体反应. 与分别接种相比,同时接种疫苗导致SARS-CoV-2抗体水平更高,更持久.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 公共卫生 公共卫生
背景情况:
- 在2022年秋季推使用双等效的COVID-19 mRNA增强剂和季节性流感疫苗.
- 同时使用这些疫苗的最佳时间尚未确定.
研究的目的:
- 为了比较两价COVID-19增剂和流感疫苗同步与单独的免疫性.
主要方法:
- 对卫生保健工作者抗体反应的分析.
- 针对SARS-CoV-2的IgG1反应的比较 根据接种时间 (同一天与不同日期) 的IgG1反应.
主要成果:
- 较高的峰值IgG1对SARS-CoV-2的反应与并发管理一起观察到.
- 持续较高的IgG1反应在接种疫苗6个月后被观察到.
结论:
- 同时服用双价COVID-19增强剂和流感疫苗可能会导致增强和更长时间的SARS-CoV-2抗体保护.
- 这些发现支持了用于改善免疫反应的同时使用策略.
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