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相关概念视频

Neurulation01:30

Neurulation

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Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
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Determination01:51

Determination

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During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In...
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相关实验视频

Updated: Jul 15, 2025

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex
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Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex

Published on: September 5, 2018

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发育中的人类皮质的元图表识别了驱动细胞亚型规范的模块.

Patricia R Nano, Elisa Fazzari, Daria Azizad

    bioRxiv : the preprint server for biology
    |September 25, 2023
    PubMed
    概括

    研究人员使用基因共同表达网络绘制了人类大脑发育的地图,确定了FEZF2和TSHZ3等关键因素,这些因素对于深层神经元形成和细胞命运规范至关重要.

    科学领域:

    • 神经科学是一个神经科学.
    • 发展生物学 发展生物学
    • 遗传学 是一个遗传学.

    背景情况:

    • 人类大脑的发育包括产生各种各样的细胞类型.
    • 单细胞转录基因分析是研究这一过程的关键技术.
    • 了解基因共同表达网络对于破译发育机制至关重要.

    研究的目的:

    • 为人类皮层发育创建基因共同表达网络 (元模块) 的综合图谱.
    • 为了确定特定的基因网络和转录因子参与细胞类型规范.
    • 为了验证已识别的因素在人类皮质器官中的作用.

    主要方法:

    • 七个单细胞转录基因数据集的元分析.
    • 产生225个基因共同表达元模块.
    • 在人类皮质组织中验证时空表达.
    • 使用人类皮质器官的功能实验.

    主要成果:

    • 确定了225个可能调节皮质发育的元模块.
    • 在人体组织中验证了几个元模块的时空表达.
    • 与FEZF2+深层神经元相关的元模块20包括TSHZ3作为FEZF2目标.

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    Visualization of Cortical Modules in Flattened Mammalian Cortices

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  • 证实FEZF2和TSHZ3是有机体中深层神经元规范所必需的.

    • 结论:

    • 超地图集为研究人类皮质发育提供了宝贵的资源.
    • FEZF2和TSHZ3在深层神经元规范中发挥着关键作用.
    • 微妙的基因操纵可以导致显著的细胞命运变化,突出显示出发育途径的敏感性.